Systematic review of genome-wide association studies of abdominal aortic aneurysm

Background and aimsAbdominal aortic aneurysm (AAA) is an important cause of death worldwide has estimated heritability between 70 77%. Genome-wide association studies (GWAS) are established way to discover genetic risk variants. The aim this study was systematically review the findings quality previous AAA GWAS.MethodsThe Medline, PubMed, Web Science relevant databases were searched identify GWAS. A framework developed grade methodological Data from included extracted assess methods findings.ResultsEight case-control included. Thirty-three 38 total single nucleotide polymorphisms (SNPs) previously reported associated with diagnosis at genome-wide significance (p < 5.0 × 10−8). CDKN2B antisense RNA-1 gene had most significant = 6.94 10−29 p 1.54 10−33 for rs4007642 rs10757274 respectively). Age, sex smoking history not complete cohort in any studies, although five eight adjusted or matched least two confounding variables. All design limitations including lack sample size estimation, inconsistent case control ascertainment limited phenotyping AAAs. growth assessed one GWAS, however, no associations SNPs found.ConclusionsThis systematic identified 33 validated multiple cohorts. adequately examined. Previous GWAS have a number limitations.